PD/Ashkenazi Jews and LRRK2 Consortium

Parkinson’s disease (PD), Ashkenazi Jews (AJ) and LRRK2 – a consortium proposal

Study Purpose:

The primary objective of this study is to collect clinical, genetic, biomarker and imaging information from Ashkenazi Jewish individuals having PD or a family member with PD. Subjects will include 300 PD patients, half of whom carry the LRRK2 G2019S mutation, as well as 300 asymptomatic family members, half of whom carry the same mutation, and 100 unrelated spouse controls. Through this study we hope to better understand the clinical genetics of LRRK2 PD, including subclinical features that may help in early detection and interverntion in the future. We also hope to identify new PD genes through GWAS and expression analyses.

Recruitment Information:

Accepts Control Volunteers: Yes Study Type: Observational
Eligible Ages: 18 - 100 Status: Recruiting
Time Since Diagnosis: Any may be eligible Study Focus: Anxiety, Biomarkers, Bradykinesia (slowness of movement), rigidity, Cause of PD, Cognitive Deficits, Constipation/Bladder Problems, Depression, Dyskinesia, Dysphagia (difficulty swallowing), Fatigue, Gait disturbances (e.g., freezing), Genetics, Hypotension (low blood pressure), Postural Instability (falling), Sexual Dysfunction, Sialorrhea (excessive salivation), Sleep Disturbances, Speech Difficulties, Tremors

More Details

More Inclusion & Exclusion Criteria

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United States
  • New York, New York
  • Beth Israel Medical Center
  • Status: Recruiting
    • Beth Israel Medical Center
      Beth Israel Medical Center, New York, New York, United States
    • Deborah Raymond
      draymond@chpnet.org
      888-228-1688
  • New York, New York
  • Columbia University
  • Status: Recruiting

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