LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease

LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease

Recruitment Information:

Seeking volunteers with following diagnosis: PD, Control Volunteers Accepted Study Type: Observational
Eligible Ages: 21 - 99 Status: Completed
Time Since Diagnosis: Less than 60 years Study Focus: Biomarkers, Bradykinesia (slowness of movement), rigidity, Tremors

Study Purpose:

This proposal seeks to 1) determine whether there are biomarkers associated with Parkinson's disease (PD) susceptibility and/or progression in exosome-proteomes derived from PD patients versus controls, and 2) to determine if LRRK2 expression and/or phosphorylation are significantly lowered in the exosomes of individuals treated with the potent LRRK2 kinase inhibitor sunitinib (a multi-kinase inhibitor compound), to establish an assay for on-target effects for future LRRK2 inhibitor clinical trials.

More Details

Phase: N/A Lead Sponsor: University of Alabama at Birmingham
Trial ID: 003350 Sponsor Type: Other
Primary Country: United States Additional Collaborators or Sponsors: National Institute of Neurological Disorders and Stroke (NINDS)
Estimated Enrollment: 700 Study Start Date: January 2013
Estimated Study Completion Date: January 2017 Source:
Study Website:

More Inclusion & Exclusion Criteria

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