Olfactory microbiome

Determining the Microbiota Composition of the Middle Meatus in Parkinson's disease

Recruitment Information:

Seeking volunteers with following diagnosis: PD, Control Volunteers Accepted Study Type: Observational
Eligible Ages: 40 - 80 Status: Recruiting
Time Since Diagnosis: Less than 20 years Study Focus: Cause of PD

Study Purpose:

The cause of Parkinson’s disease (PD) is currently unknown. However, there is growing evidence that the gastrointestinal (GI) system is the port of entry of causative toxins or molecular alterations, specifically facilitated by GI inflammation. This inflammation may be due to transformation of the healthy microbiota environment into a toxic environment, as our work has shown that the mucosal and fecal microbial community of PD subjects is very different from that of healthy subjects. Swabbing the nasal mucosa represents a relatively non-invasive, easy to perform and very rapid office procedure that can be implemented with minimal discomfort. The identification of nasal markers that resemble those already found in the gastrointestinal tract and that distinguish PD subjects from healthy controls is a critical and necessary step in the development of treatments that can target these markers through the entire body with the aim of monitoring disease progression and developing new treatments against these inflammatory responses from the very earliest phase of Parkinson’s disease. Because loss of smell is one of the earliest clinical components of Parkinson’s disease, the target of the olfactory system is clinically and scientifically a strong candidate for biomarker research.

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More Details

Phase: Observational Lead Sponsor:
Trial ID: 005107 Sponsor Type: Other
Primary Country: United States Additional Collaborators or Sponsors:
Estimated Enrollment: 0 Study Start Date: July 2017
Estimated Study Completion Date: July 2019 Source:
Study Website:

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